To me, McNabb is the clear number one pick for this year. BUT, there is enough depth that I would avoid taking a quarterback early and see what you can pick up in later rounds.
My strategy will call for taking RBs for probably the first 2 rounds.
IMO, Vick is going to be taken way higher than he should be. I see decent value in Plummer, Culpepper, and possibly even Kitna in middle rounds.
Also depends how your league is set up...