Had a Logitech 600, kind of old school but loved it, controlled 2 tv's, amp roku, cable very cleanly. We've only looked into Logitechs as they seem to deliver the biggest bang for the buck without spending the really bucks. Do you have one you like/recommend?
I can't recommend the Harmony remotes enough. Excellent functionality, can be programmed easily to control anything. Pick the one that fits your budget.