| Player | Team | Pos | Injury | Status | Est. Return |
| Carter O'Donnell | ARI | OG | Undisclosed | IR | 2/10/2025 |
| BJ Ojulari | ARI | DE | Knee - ACL | IR | 2/10/2025 |
| Zay Jones | ARI | WR | Suspension | Reserve-Sus | 10/13/2024 |
| Christian Jones | ARI | OT | Ankle | IR-R | 10/6/2024 |
| Elijah Jones | ARI | CB | Heel | IR | 10/6/2024 |
| Darius Robinson | ARI | DE | Calf | IR-R | 10/6/2024 |
| Jon Gaines | ARI | C | Finger | Questionable | 9/8/2024 |
| Darren Hall | ARI | CB | Hip | Questionable | 9/8/2024 |
| Tip Reiman | ARI | TE | Undisclosed | Questionable | 9/8/2024 |
| Xavier Weaver | ARI | WR | Oblique | Questionable | 9/8/2024 |
| Robert Burns | ATL | FB | Undisclosed | PUP-R | 2/10/2025 |
| Milo Eifler | ATL | LB | Undisclosed | IR | 2/10/2025 |
| Harrison Hand | ATL | CB | Knee | IR | 2/10/2025 |
| Rondale Moore | ATL | WR | Knee | IR | 2/10/2025 |
| Josh Thompson | ATL | S | Undisclosed | IR | 2/10/2025 |
| Bralen Trice | ATL | LB | Knee - ACL | IR | 2/10/2025 |
| Tyler Vrabel | ATL | OT | Undisclosed | Reserve-Ret | 2/10/2025 |
| DeMarcco Hellams | ATL | S | Ankle | IR-R | 10/3/2024 |
| Kaden Elliss | ATL | LB | Groin | Questionable | 9/8/2024 |
| Nate Landman | ATL | LB | Quadriceps | Questionable | 9/8/2024 |
| Kyle Pitts | ATL | TE | Hamstring | Questionable | 9/8/2024 |
| Malik Hamm | BAL | LB | Knee - ACL | IR | 2/10/2025 |
| Deion Jennings | BAL | LB | Undisclosed | IR | 2/10/2025 |
| Christian Matthew | BAL | CB | Undisclosed | IR | 2/10/2025 |
| Trayvon Mullen | BAL | CB | Shoulder | IR | 2/10/2025 |
| Isaiah Washington | BAL | WR | Undisclosed | IR | 2/10/2025 |
| Owen Wright | BAL | RB | Foot | IR | 2/10/2025 |
| Keaton Mitchell | BAL | RB | Knee - ACL | PUP-R | 11/3/2024 |
| Arthur Maulet | BAL | CB | Knee | IR-R | 10/6/2024 |
| Rasheen Ali | BAL | RB | Neck | Questionable | 9/5/2024 |
| Adisa Isaac | BAL | LB | Hamstring | Questionable | 9/5/2024 |
| Shane Buechele | BUF | QB | Neck | IR | 2/10/2025 |
| Travis Clayton | BUF | OT | Shoulder | IR | 2/10/2025 |
| Tommy Doyle | BUF | OT | Knee | PUP-R | 2/10/2025 |
| Brandon Shell | BUF | OT | Undisclosed | Reserve-Ret | 2/10/2025 |
| Matt Milano | BUF | LB | Biceps | IR-R | 12/1/2024 |
| Darrynton Evans | BUF | RB | Hamstring | IR-R | 10/6/2024 |
| Cole Bishop | BUF | S | Shoulder | Questionable | 9/8/2024 |
| Mike Edwards | BUF | S | Hamstring | Questionable | 9/8/2024 |
| Damar Hamlin | BUF | S | Hamstring | Questionable | 9/8/2024 |
| Austin Johnson | BUF | DT | Calf | Questionable | 9/8/2024 |
| Taron Johnson | BUF | CB | Quadriceps | Questionable | 9/8/2024 |
| Quintin Morris | BUF | TE | Shoulder | Questionable | 9/8/2024 |
| Nicholas Morrow | BUF | LB | Groin | Questionable | 9/8/2024 |
| Curtis Samuel | BUF | WR | Toe | Questionable | 9/8/2024 |
| Javon Solomon | BUF | DE | Calf | Questionable | 9/8/2024 |
| Baylon Spector | BUF | LB | Calf | Questionable | 9/8/2024 |
| Mitchell Trubisky | BUF | QB | Knee | Questionable | 9/8/2024 |
| Marquez Valdes-Scantling | BUF | WR | Neck | Questionable | 9/8/2024 |
| Popo Aumavae | CAR | DT | Undisclosed | IR | 2/10/2025 |
| Anthony Brown | CAR | CB | Thumb | IR | 2/10/2025 |
| Devin Carter | CAR | WR | Undisclosed | IR | 2/10/2025 |
| Cam Gill | CAR | LB | Ankle | IR | 2/10/2025 |
| Raequan Williams | CAR | DT | Undisclosed | IR | 2/10/2025 |
| Amare Barno | CAR | LB | Knee | PUP-R | 10/6/2024 |
| Jonathon Brooks | CAR | RB | Knee - ACL | NFI-R | 10/6/2024 |
| Jaden Crumedy | CAR | DT | Ankle | IR | 10/6/2024 |
| Sam Franklin | CAR | S | Foot | IR-R | 10/6/2024 |
| Dane Jackson | CAR | CB | Hamstring | IR-R | 10/6/2024 |
| D.J. Wonnum | CAR | LB | Quadriceps | PUP-R | 10/6/2024 |
| Jadeveon Clowney | CAR | LB | Illness | Questionable | 9/8/2024 |
| Eddy Pineiro | CAR | K | Hamstring | Questionable | 9/8/2024 |
| Ian Thomas | CAR | TE | Calf | Questionable | 9/8/2024 |
| Tommy Tremble | CAR | TE | Hamstring | Questionable | 9/8/2024 |
| Xavier Woods | CAR | S | Groin | Questionable | 9/8/2024 |
| Douglas Coleman | CHI | S | Upper Body | IR | 2/10/2025 |
| Dante Pettis | CHI | WR | Undisclosed | IR | 2/10/2025 |
| Nsimba Webster | CHI | WR | Groin | IR | 2/10/2025 |
| Ian Wheeler | CHI | RB | Knee | IR | 2/10/2025 |
| Larry Borom | CHI | OT | Ankle | IR-R | 10/6/2024 |
| Jake Martin | CHI | DE | Undisclosed | IR-R | 10/6/2024 |
| Patrick Scales | CHI | C | Back | IR | 10/6/2024 |
| Keenan Allen | CHI | WR | Foot | Questionable | 9/8/2024 |
| Jaquan Brisker | CHI | S | Undisclosed | Questionable | 9/8/2024 |
| Kevin Byard | CHI | S | Undisclosed | Questionable | 9/8/2024 |
| Chris Evans | CIN | RB | Leg | IR | 2/10/2025 |
| Jeff Gunter | CIN | DE | Undisclosed | Reserve-Ret | 2/10/2025 |
| Lance Robinson | CIN | CB | Undisclosed | IR | 2/10/2025 |
| Cameron Sample | CIN | DE | Achilles | IR | 2/10/2025 |
| D'Ante Smith | CIN | OT | Leg | IR | 2/10/2025 |
| DJ Ivey | CIN | CB | Knee - ACL | PUP-R | 10/6/2024 |
| McKinnley Jackson | CIN | DT | Knee | IR | 10/6/2024 |
| Myles Murphy | CIN | DE | Knee | IR-R | 10/6/2024 |
| Brad Robbins | CIN | P | Upper Leg | IR-R | 10/6/2024 |
| Jake Browning | CIN | QB | Ribs | Questionable | 9/8/2024 |
| Sam Hubbard | CIN | DE | Knee | Questionable | 9/8/2024 |
| Amarius Mims | CIN | OT | Pectoral | Questionable | 9/8/2024 |
| Hakeem Adeniji | CLE | OT | Knee | IR | 2/10/2025 |
| Brandon Bouyer-Randle | CLE | LB | Undisclosed | IR | 2/10/2025 |
| Chase Williams | CLE | CB | Head | IR | 2/10/2025 |
| Luke Wypler | CLE | C | Ankle | IR | 2/10/2025 |
| Nick Chubb | CLE | RB | Knee - ACL + MCL | PUP-R | 10/6/2024 |
| Michael Dunn | CLE | OG | Undisclosed | NFI-R | 10/6/2024 |
| Nyheim Hines | CLE | RB | Knee - ACL | NFI-R | 10/6/2024 |
| David Bell | CLE | WR | Quadriceps | Questionable | 9/8/2024 |
| Michael Hall | CLE | DT | Neck | Reserve-CEL | 9/8/2024 |
| Jordan Hicks | CLE | LB | Undisclosed | Questionable | 9/8/2024 |
| Dustin Hopkins | CLE | K | Undisclosed | Questionable | 9/8/2024 |
| James Hudson | CLE | OT | Ankle | Questionable | 9/8/2024 |
| Maurice Hurst | CLE | DT | Undisclosed | Questionable | 9/8/2024 |
| David Njoku | CLE | TE | Undisclosed | Questionable | 9/8/2024 |
| Pierre Strong | CLE | RB | Ribs | Questionable | 9/8/2024 |
| Nathaniel Watson | CLE | LB | Quadriceps | Questionable | 9/8/2024 |
| Jedrick Wills | CLE | OT | Knee - MCL | Questionable | 9/8/2024 |
| Earl Bostick | DAL | OT | Leg | IR | 2/10/2025 |
| Durrell Johnson | DAL | DE | Undisclosed | IR | 2/10/2025 |
| Nathan Thomas | DAL | OT | Undisclosed | IR | 2/10/2025 |
| Sam Williams | DAL | DE | Knee - ACL | IR | 2/10/2025 |
| DaRon Bland | DAL | CB | Foot | IR-R | 10/6/2024 |
| Chuma Edoga | DAL | OT | Toe | IR | 10/6/2024 |
| Damone Clark | DAL | LB | Knee | Questionable | 9/8/2024 |
| Brandin Cooks | DAL | WR | Knee | Questionable | 9/8/2024 |
| Tyler Guyton | DAL | OT | Knee | Questionable | 9/8/2024 |
| Eric Kendricks | DAL | LB | Back | Questionable | 9/8/2024 |
| CeeDee Lamb | DAL | WR | Personal | Reserve-CEL | 9/8/2024 |
| DeMarvion Overshown | DAL | LB | Hip | Questionable | 9/8/2024 |
| Quinn Bailey | DEN | OT | Ankle | IR | 2/10/2025 |
| Durell Nchami | DEN | LB | Undisclosed | IR | 2/10/2025 |
| Ronnie Perkins | DEN | LB | Undisclosed | IR | 2/10/2025 |
| Drew Sanders | DEN | LB | Achilles | PUP-R | 11/24/2024 |
| Damarri Mathis | DEN | CB | Ankle | IR-R | 10/6/2024 |
| Delarrin Turner-Yell | DEN | S | Knee - ACL | PUP-R | 10/6/2024 |
| Brandon Jones | DEN | S | Hamstring | Questionable | 9/8/2024 |
| Ben Powers | DEN | OG | Ribs | Questionable | 9/8/2024 |
| Josh Reynolds | DEN | WR | Achilles | Questionable | 9/8/2024 |
| David Bada | DET | DT | Achilles | IR | 2/10/2025 |
| Michael Badgley | DET | K | Hamstring | IR | 2/10/2025 |
| Connor Galvin | DET | OT | Knee - MCL | IR | 2/10/2025 |
| Antoine Green | DET | WR | Concussion | IR | 2/10/2025 |
| Nate Lynn | DET | DE | Shoulder | IR | 2/10/2025 |
| Netane Muti | DET | OG | Shoulder | IR | 2/10/2025 |
| Tre'Quan Smith | DET | WR | Undisclosed | IR | 2/10/2025 |
| John Cominsky | DET | DE | Knee - MCL | IR | 1/5/2025 |
| Christian Mahogany | DET | OG | Illness | NFI-R | 10/13/2024 |
| Brodric Martin | DET | DT | Leg | IR-R | 10/13/2024 |
| Emmanuel Moseley | DET | CB | Pectoral | IR-R | 10/13/2024 |
| Jahmyr Gibbs | DET | RB | Hamstring | Questionable | 9/8/2024 |
| Sam LaPorta | DET | TE | Hamstring | Questionable | 9/8/2024 |
| Ifeatu Melifonwu | DET | S | Undisclosed | Questionable | 9/8/2024 |
| DJ Reader | DET | DT | Quadriceps | Questionable | 9/8/2024 |
| Craig Reynolds | DET | RB | Leg | Questionable | 9/8/2024 |
| Penei Sewell | DET | OT | Ankle | Questionable | 9/8/2024 |
| L.J. Davis | GB | CB | Undisclosed | IR | 2/10/2025 |
| Tyler Davis | GB | TE | Shoulder | IR | 2/10/2025 |
| AJ Dillon | GB | RB | Neck | IR | 2/10/2025 |
| Ralen Goforth | GB | LB | Ankle | IR | 2/10/2025 |
| Jonathan Ford | GB | DT | Calf | IR-R | 10/6/2024 |
| Arron Mosby | GB | DE | Personal | Out | 9/15/2024 |
| Edgerrin Cooper | GB | LB | Groin | Questionable | 9/6/2024 |
| Romeo Doubs | GB | WR | Hand | Questionable | 9/6/2024 |
| Tucker Kraft | GB | TE | Back | Questionable | 9/6/2024 |
| MarShawn Lloyd | GB | RB | Hamstring | Questionable | 9/6/2024 |
| Carrington Valentine | GB | CB | Hamstring | Questionable | 9/6/2024 |
| Emanuel Wilson | GB | RB | Hip | Questionable | 9/6/2024 |
| Brandon Hill | HOU | S | Leg | IR | 2/10/2025 |
| Dalton Keene | HOU | TE | Knee - ACL | IR | 2/10/2025 |
| Case Keenum | HOU | QB | Foot | IR | 2/10/2025 |
| Teagan Quitoriano | HOU | TE | Calf | IR | 2/10/2025 |
| Jaylon Thomas | HOU | OG | Undisclosed | IR | 2/10/2025 |
| Denico Autry | HOU | DT | Suspension | Reserve-Sus | 10/20/2024 |
| Christian Harris | HOU | LB | Calf | IR-R | 10/6/2024 |
| LaDarius Henderson | HOU | OG | Foot | NFI-R | 10/6/2024 |
| Kurt Hinish | HOU | DT | Undisclosed | IR-R | 10/6/2024 |
| Dylan Horton | HOU | DE | Illness | NFI-R | 10/6/2024 |
| Will Anderson | HOU | DE | Ankle | Questionable | 9/8/2024 |
| Kris Boyd | HOU | CB | Leg | Questionable | 9/8/2024 |
| Ryan Coll | IND | C | Undisclosed | IR | 2/10/2025 |
| Wesley French | IND | C | Ankle | IR | 2/10/2025 |
| Daniel Scott | IND | S | Achilles | IR | 2/10/2025 |
| Juwann Winfree | IND | WR | Undisclosed | IR | 2/10/2025 |
| Jelani Woods | IND | TE | Toe | IR | 2/10/2025 |
| Samson Ebukam | IND | DE | Achilles | IR-R | 10/6/2024 |
| Cameron McGrone | IND | LB | Undisclosed | IR-R | 10/6/2024 |
| Tanor Bortolini | IND | C | Toe | Questionable | 9/8/2024 |
| JuJu Brents | IND | CB | Nose | Questionable | 9/8/2024 |
| Josh Downs | IND | WR | Ankle | Questionable | 9/8/2024 |
| Matt Gay | IND | K | Groin | Questionable | 9/8/2024 |
| Trey Sermon | IND | RB | Hamstring | Questionable | 9/8/2024 |
| De'Shaan Dixon | JAX | LB | Knee - ACL | IR | 2/10/2025 |
| Patrick Murtagh | JAX | TE | Ankle | IR | 2/10/2025 |
| David White | JAX | WR | Knee - ACL | IR | 2/10/2025 |
| Tashaun Gipson | JAX | S | Suspension | Reserve-Sus | 10/20/2024 |
| Keilan Robinson | JAX | RB | Toe | IR-R | 10/6/2024 |
| Andrew Wingard | JAX | S | Knee | IR-R | 10/6/2024 |
| Christian Kirk | JAX | WR | Calf | Questionable | 9/8/2024 |
| Foye Oluokun | JAX | LB | Hamstring | Questionable | 9/8/2024 |
| Daniel Thomas | JAX | S | Heel | Questionable | 9/8/2024 |
| Tyree Gillespie | KC | S | Undisclosed | IR | 2/10/2025 |
| Jaaron Hayek | KC | WR | Shoulder | IR | 2/10/2025 |
| McKade Mettauer | KC | OG | Knee - MCL | IR | 2/10/2025 |
| Clyde Edwards-Helaire | KC | RB | Illness | NFI-R | 10/7/2024 |
| Charles Omenihu | KC | DE | Knee - ACL | PUP-R | 10/7/2024 |
| BJ Thompson | KC | DE | Undisclosed | NFI-R | 10/7/2024 |
| Marquise Brown | KC | WR | Shoulder | Out | 9/15/2024 |
| Chris Collins | LAC | LB | Undisclosed | IR | 2/10/2025 |
| Tyler McLellan | LAC | OT | Undisclosed | IR | 2/10/2025 |
| Chris Rumph | LAC | LB | Foot | IR | 2/10/2025 |
| Bucky Williams | LAC | C | Undisclosed | IR | 2/10/2025 |
| Nick Niemann | LAC | LB | Undisclosed | IR-R | 10/13/2024 |
| Joey Bosa | LAC | LB | Hand | Questionable | 9/8/2024 |
| DJ Chark | LAC | WR | Hip | Questionable | 9/8/2024 |
| Justin Herbert | LAC | QB | Foot | Questionable | 9/8/2024 |
| Anthony Goodlow | LAR | DE | Undisclosed | IR | 2/10/2025 |
| Derion Kendrick | LAR | CB | Knee | IR | 2/10/2025 |
| Tre Tomlinson | LAR | CB | Undisclosed | IR | 2/10/2025 |
| Tyler Higbee | LAR | TE | Knee - ACL + MCL | PUP-R | 10/6/2024 |
| KT Leveston | LAR | OG | Ankle | IR-R | 10/6/2024 |
| Conor McDermott | LAR | OT | Undisclosed | IR | 10/6/2024 |
| Larrell Murchison | LAR | DT | Arm | IR-R | 10/6/2024 |
| Jimmy Garoppolo | LAR | QB | Suspension | Reserve-Sus | 9/22/2024 |
| Alaric Jackson | LAR | OT | Suspension | Reserve-Sus | 9/22/2024 |
| Rob Havenstein | LAR | OT | Ankle | Questionable | 9/8/2024 |
| Brennan Jackson | LAR | LB | Undisclosed | Questionable | 9/8/2024 |
| Jonah Jackson | LAR | C | Shoulder | Questionable | 9/8/2024 |
| Puka Nacua | LAR | WR | Knee | Questionable | 9/8/2024 |
| Jeff Foreman | LV | WR | Knee | IR | 2/10/2025 |
| Tomari Fox | LV | DT | Undisclosed | IR | 2/10/2025 |
| Jake Johanning | LV | OG | Undisclosed | IR | 2/10/2025 |
| Ron Stone | LV | DE | Undisclosed | IR | 2/10/2025 |
| Trey Taylor | LV | S | Undisclosed | IR-R | 10/6/2024 |
| Davante Adams | LV | WR | Undisclosed | Questionable | 9/8/2024 |
| Brock Bowers | LV | TE | Foot | Questionable | 9/8/2024 |
| Cam Brown | MIA | LB | Undisclosed | IR | 2/10/2025 |
| Ryan Hayes | MIA | OT | Foot | IR | 2/10/2025 |
| Grayson Murphy | MIA | LB | Knee | IR | 2/10/2025 |
| Wyatt Ray | MIA | LB | Undisclosed | IR | 2/10/2025 |
| Braylon Sanders | MIA | WR | Lower Body | IR | 2/10/2025 |
| Anthony Schwartz | MIA | WR | Knee | IR | 2/10/2025 |
| Kion Smith | MIA | OT | Knee - ACL | IR | 2/10/2025 |
| Tahj Washington | MIA | WR | Undisclosed | IR | 2/10/2025 |
| Odell Beckham | MIA | WR | Undisclosed | PUP-R | 10/6/2024 |
| Bradley Chubb | MIA | LB | Knee - ACL | PUP-R | 10/6/2024 |
| River Cracraft | MIA | WR | Upper Body | IR-R | 10/6/2024 |
| Cameron Goode | MIA | LB | Kneecap | PUP-R | 10/6/2024 |
| Patrick McMorris | MIA | S | Foot | IR | 10/6/2024 |
| Cam Smith | MIA | CB | Hamstring | IR-R | 10/6/2024 |
| Isaiah Wynn | MIA | OG | Quadriceps | PUP-R | 10/6/2024 |
| Aaron Brewer | MIA | C | Hand | Questionable | 9/8/2024 |
| Jevon Holland | MIA | S | Undisclosed | Questionable | 9/8/2024 |
| Jaelan Phillips | MIA | LB | Achilles | Questionable | 9/8/2024 |
| Jordan Poyer | MIA | S | Thumb | Questionable | 9/8/2024 |
| Jalen Ramsey | MIA | CB | Undisclosed | Questionable | 9/8/2024 |
| Jaylen Waddle | MIA | WR | Undisclosed | Questionable | 9/8/2024 |
| Anthony Walker | MIA | LB | Undisclosed | Questionable | 9/8/2024 |
| Mekhi Blackmon | MIN | CB | Knee - ACL | IR | 2/10/2025 |
| Jeremy Flax | MIN | OT | Undisclosed | IR | 2/10/2025 |
| Jordan Kunaszyk | MIN | LB | Undisclosed | IR | 2/10/2025 |
| J.J. McCarthy | MIN | QB | Knee - Meniscus | IR | 2/10/2025 |
| NaJee Thompson | MIN | CB | Knee | IR | 2/10/2025 |
| T.J. Hockenson | MIN | TE | Knee - ACL + MCL | PUP-R | 10/6/2024 |
| Gabriel Murphy | MIN | DE | Undisclosed | IR-R | 10/6/2024 |
| Dalton Risner | MIN | OG | Undisclosed | IR-R | 10/6/2024 |
| Jordan Addison | MIN | WR | Ankle | Questionable | 9/8/2024 |
| Blake Cashman | MIN | LB | Finger | Questionable | 9/8/2024 |
| Nick Muse | MIN | TE | Undisclosed | Questionable | 9/8/2024 |
| Jerry Tillery | MIN | DT | Lower Leg | Questionable | 9/8/2024 |
| Jake Andrews | NE | C | Undisclosed | IR | 2/10/2025 |
| JaQuae Jackson | NE | WR | Knee | IR | 2/10/2025 |
| Armon Watts | NE | DT | Undisclosed | IR | 2/10/2025 |
| Tyrone Wheatley | NE | OT | Undisclosed | IR | 2/10/2025 |
| Christian Barmore | NE | DT | Illness | NFI-R | 10/6/2024 |
| Kendrick Bourne | NE | WR | Knee - ACL | PUP-R | 10/6/2024 |
| Marte Mapu | NE | S | Undisclosed | IR-R | 10/6/2024 |
| Cole Strange | NE | OG | Knee | PUP-R | 10/6/2024 |
| Sione Takitaki | NE | LB | Knee | PUP-R | 10/6/2024 |
| Christian Elliss | NE | LB | Head | Questionable | 9/8/2024 |
| Hunter Henry | NE | TE | Undisclosed | Questionable | 9/8/2024 |
| Vederian Lowe | NE | OT | Oblique | Questionable | 9/8/2024 |
| Sidy Sow | NE | OG | Ankle | Questionable | 9/8/2024 |
| Justin Herron | NO | OT | Knee | IR | 2/10/2025 |
| Camron Peterson | NO | DT | Undisclosed | IR | 2/10/2025 |
| Ryan Ramczyk | NO | OT | Knee | PUP-R | 2/10/2025 |
| Rejzohn Wright | NO | CB | Undisclosed | IR | 2/10/2025 |
| Jabari Zuniga | NO | DE | Undisclosed | Reserve-Ret | 2/10/2025 |
| Tanoh Kpassagnon | NO | DE | Achilles | PUP-R | 10/7/2024 |
| Kendre Miller | NO | RB | Hamstring | IR-R | 10/7/2024 |
| Nephi Sewell | NO | LB | Knee - ACL | PUP-R | 10/7/2024 |
| Demario Davis | NO | LB | Hamstring | Questionable | 9/8/2024 |
| Jaylan Ford | NO | LB | Hamstring | Questionable | 9/8/2024 |
| Taliese Fuaga | NO | OT | Back | Questionable | 9/8/2024 |
| Willie Gay | NO | LB | Undisclosed | Questionable | 9/8/2024 |
| Dallin Holker | NO | TE | Ankle | Questionable | 9/8/2024 |
| D'Marco Jackson | NO | LB | Calf | Questionable | 9/8/2024 |
| Marshon Lattimore | NO | CB | Hip | Questionable | 9/8/2024 |
| Kool-Aid McKinstry | NO | CB | Knee | Questionable | 9/8/2024 |
| Khalen Saunders | NO | DT | Calf | Questionable | 9/8/2024 |
| Rashid Shaheed | NO | WR | Toe | Questionable | 9/8/2024 |
| Mason Tipton | NO | WR | Hamstring | Questionable | 9/8/2024 |
| Pete Werner | NO | LB | Shoulder | Questionable | 9/8/2024 |
| Yodny Cajuste | NYG | OT | Leg | IR | 2/10/2025 |
| Chase Cota | NYG | WR | Collarbone | IR | 2/10/2025 |
| Timmy Horne | NYG | DT | Achilles | IR | 2/10/2025 |
| Elijah Riley | NYG | S | Concussion | IR | 2/10/2025 |
| Jonathan Sutherland | NYG | S | Undisclosed | IR | 2/10/2025 |
| Matthew Adams | NYG | LB | Groin | IR-R | 10/6/2024 |
| Dyontae Johnson | NYG | LB | Ankle | IR | 10/6/2024 |
| Austin Schlottmann | NYG | OG | Leg | IR | 10/6/2024 |
| Carter Coughlin | NYG | LB | Lower Body | Questionable | 9/8/2024 |
| Cor'Dale Flott | NYG | CB | Quadriceps | Questionable | 9/8/2024 |
| Drew Lock | NYG | QB | Hip | Questionable | 9/8/2024 |
| Micah McFadden | NYG | LB | Hip | Questionable | 9/8/2024 |
| Evan Neal | NYG | OT | Ankle | Questionable | 9/8/2024 |
| Gunner Olszewski | NYG | WR | Groin | Questionable | 9/8/2024 |
| Jon Runyan | NYG | OG | Shoulder | Questionable | 9/8/2024 |
| John Michael Schmitz | NYG | C | Ankle | Questionable | 9/8/2024 |
| Tyrone Tracy | NYG | RB | Ankle | Questionable | 9/8/2024 |
| Jimmy Ciarlo | NYJ | LB | Knee - ACL | IR | 2/10/2025 |
| Marcus Riley | NYJ | WR | Undisclosed | IR | 2/10/2025 |
| Malik Taylor | NYJ | WR | Undisclosed | IR | 2/10/2025 |
| Leki Fotu | NYJ | DT | Hamstring | IR-R | 10/6/2024 |
| Jordan Travis | NYJ | QB | Ankle | NFI-R | 10/6/2024 |
| Kenny Yeboah | NYJ | TE | Groin | IR-R | 10/6/2024 |
| Jarrick Bernard-Converse | NYJ | S | Groin | Questionable | 9/9/2024 |
| Michael Carter | NYJ | CB | Ankle | Questionable | 9/9/2024 |
| Irvin Charles | NYJ | WR | Hip | Questionable | 9/9/2024 |
| Max Mitchell | NYJ | OT | Shoulder | Questionable | 9/9/2024 |
| Xavier Newman | NYJ | OG | Shoulder | Questionable | 9/9/2024 |
| Haason Reddick | NYJ | DE | Contract Dispute | Reserve-DNR | 9/9/2024 |
| Tyron Smith | NYJ | OT | Undisclosed | Questionable | 9/9/2024 |
| Mike Williams | NYJ | WR | Knee - ACL | Questionable | 9/9/2024 |
| Quinnen Williams | NYJ | DT | Shoulder | Questionable | 9/9/2024 |
| McCallan Castles | PHI | TE | Undisclosed | IR | 2/10/2025 |
| Le'Raven Clark | PHI | OT | Undisclosed | IR | 2/10/2025 |
| Jacob Harris | PHI | WR | Concussion | IR | 2/10/2025 |
| Matt Leo | PHI | DE | Undisclosed | Reserve-Ret | 2/10/2025 |
| Joseph Ngata | PHI | WR | Ankle | IR | 2/10/2025 |
| James Bradberry | PHI | S | Lower Leg | IR | 10/13/2024 |
| Sydney Brown | PHI | S | Knee - ACL | PUP-R | 10/13/2024 |
| Albert Okwuegbunam | PHI | TE | Abdomen | IR-R | 10/13/2024 |
| Ainias Smith | PHI | WR | Ankle | IR-R | 10/13/2024 |
| Devin White | PHI | LB | Ankle | Out | 9/16/2024 |
| Isaiah Rodgers | PHI | CB | Hand | Questionable | 9/6/2024 |
| Markus Golden | PIT | LB | Undisclosed | Reserve-Ret | 2/10/2025 |
| Nate Herbig | PIT | OG | Shoulder | IR | 2/10/2025 |
| David Perales | PIT | LB | Knee | IR | 2/10/2025 |
| Ryan Watts | PIT | S | Undisclosed | IR | 2/10/2025 |
| Cameron Sutton | PIT | CB | Suspension | Reserve-Sus | 11/10/2024 |
| Dylan Cook | PIT | OT | Undisclosed | IR-R | 10/6/2024 |
| Cole Holcomb | PIT | LB | Knee | PUP-R | 10/6/2024 |
| Jeremiah Moon | PIT | LB | Undisclosed | IR-R | 10/6/2024 |
| Isaac Seumalo | PIT | OG | Pectoral | Out | 9/15/2024 |
| Troy Fautanu | PIT | OT | Knee - MCL | Questionable | 9/8/2024 |
| Cory Trice | PIT | CB | Groin | Questionable | 9/8/2024 |
| Jaylen Warren | PIT | RB | Hamstring | Questionable | 9/8/2024 |
| Payton Wilson | PIT | LB | Head | Questionable | 9/8/2024 |
| Roman Wilson | PIT | WR | Ankle | Questionable | 9/8/2024 |
| Joshua Onujiogu | SEA | LB | Undisclosed | IR | 2/10/2025 |
| Marcus Simms | SEA | WR | Undisclosed | IR | 2/10/2025 |
| Abraham Lucas | SEA | OT | Knee | PUP-R | 10/6/2024 |
| Jerrick Reed | SEA | S | Knee - ACL | PUP-R | 10/6/2024 |
| Cameron Young | SEA | DT | Undisclosed | PUP-R | 10/6/2024 |
| Uchenna Nwosu | SEA | LB | Knee - MCL | Out | 9/15/2024 |
| Jerome Baker | SEA | LB | Hamstring | Questionable | 9/8/2024 |
| Pharaoh Brown | SEA | TE | Foot | Questionable | 9/8/2024 |
| Zach Charbonnet | SEA | RB | Undisclosed | Questionable | 9/8/2024 |
| Noah Fant | SEA | TE | Foot | Questionable | 9/8/2024 |
| Tyler Lockett | SEA | WR | Leg | Questionable | 9/8/2024 |
| Drake Jackson | SF | DE | Knee | PUP-R | 2/10/2025 |
| Elijah Mitchell | SF | RB | Hamstring | IR | 2/10/2025 |
| Kalia Davis | SF | DT | Knee | IR-R | 11/10/2024 |
| Jon Feliciano | SF | OG | Knee | IR | 10/6/2024 |
| Dre Greenlaw | SF | LB | Achilles | PUP-R | 10/6/2024 |
| Ricky Pearsall | SF | WR | Chest | NFI-R | 10/6/2024 |
| Ambry Thomas | SF | CB | Forearm | IR | 10/6/2024 |
| Aaron Banks | SF | OG | Finger | Questionable | 9/9/2024 |
| Spencer Burford | SF | OG | Hand | Questionable | 9/9/2024 |
| Leonard Floyd | SF | DE | Knee | Questionable | 9/9/2024 |
| Yetur Gross-Matos | SF | LB | Knee | Questionable | 9/9/2024 |
| Isaac Guerendo | SF | RB | Groin | Questionable | 9/9/2024 |
| Talanoa Hufanga | SF | S | Knee - ACL | Questionable | 9/9/2024 |
| Jauan Jennings | SF | WR | Oblique | Questionable | 9/9/2024 |
| Christian McCaffrey | SF | RB | Calf | Questionable | 9/9/2024 |
| Fred Warner | SF | LB | Foot | Questionable | 9/9/2024 |
| Dee Winters | SF | LB | Ankle | Questionable | 9/9/2024 |
| Silas Dzansi | TB | OT | Knee | IR | 2/10/2025 |
| Chase Edmonds | TB | RB | Knee | IR | 2/10/2025 |
| Sua Opeta | TB | OG | Knee - ACL | IR | 2/10/2025 |
| Shaun Peterson | TB | LB | Undisclosed | IR | 2/10/2025 |
| Lwal Uguak | TB | DT | Undisclosed | IR | 2/10/2025 |
| Rakim Jarrett | TB | WR | Undisclosed | IR-R | 10/3/2024 |
| SirVocea Dennis | TB | LB | Undisclosed | Questionable | 9/8/2024 |
| Yaya Diaby | TB | LB | Ankle | Questionable | 9/8/2024 |
| Tyrek Funderburk | TB | CB | Foot | Questionable | 9/8/2024 |
| Christian Izien | TB | CB | Leg | Questionable | 9/8/2024 |
| Kaevon Merriweather | TB | S | Knee | Questionable | 9/8/2024 |
| Trey Palmer | TB | WR | Undisclosed | Questionable | 9/8/2024 |
| Joe Tryon-Shoyinka | TB | LB | Shoulder | Questionable | 9/8/2024 |
| Chance Campbell | TEN | LB | Knee - ACL | IR | 2/10/2025 |
| Saahdiq Charles | TEN | OG | Personal | Reserve-Ret | 2/10/2025 |
| Marlon Davidson | TEN | DT | Biceps | IR | 2/10/2025 |
| JoJo Domann | TEN | LB | Undisclosed | IR | 2/10/2025 |
| TK McLendon | TEN | DE | Toe | IR | 2/10/2025 |
| Lachavious Simmons | TEN | OG | Undisclosed | IR | 2/10/2025 |
| Garret Wallow | TEN | LB | Pectoral | IR | 2/10/2025 |
| Colton Dowell | TEN | WR | Knee - ACL | PUP-R | 10/13/2024 |
| Cedric Gray | TEN | LB | Shoulder | IR | 10/13/2024 |
| Jamal Adams | TEN | S | General Soreness | Questionable | 9/8/2024 |
| Chidobe Awuzie | TEN | CB | Calf | Questionable | 9/8/2024 |
| DeAndre Hopkins | TEN | WR | Knee | Questionable | 9/8/2024 |
| Arden Key | TEN | LB | Hamstring | Questionable | 9/8/2024 |
| Otis Reese | TEN | LB | Concussion | Questionable | 9/8/2024 |
| Josh Whyle | TEN | TE | Concussion | Questionable | 9/8/2024 |
| Norell Pollard | WAS | DT | Undisclosed | IR | 2/10/2025 |
| Taylor Stallworth | WAS | DT | Undisclosed | IR | 2/10/2025 |
| Armani Taylor-Prioleau | WAS | OT | Undisclosed | IR | 2/10/2025 |
| Jordan Magee | WAS | LB | Knee - Meniscus | IR-R | 10/6/2024 |
| Efe Obada | WAS | DE | Lower Leg | PUP-R | 10/6/2024 |
| Brandon Coleman | WAS | OT | Pectoral | Questionable | 9/8/2024 |
| Marcus Mariota | WAS | QB | Groin | Questionable | 9/8/2024 |
| Jer'Zhan Newton | WAS | DT | Undisclosed | Questionable | 9/8/2024 |
Thank you
