I lay heavy chalk from time to time, even down to -1000.
I don't do it for US-sports though, just on games in some lower divisions over here in Europe since there is a huge difference in team quality (typically you get scores like 8-1 in hockey, 21-0 in baseball or 8-0 in soccer for such games) and I tend to put them into 2-,3- or 4-team parlays, most of the time involving at least one team around -200, so that I get a -125 to +100 payout on the parlay.