This leaves only Daniel Jones, Darren Waller and Matt Breida to lead the attack against Fred Warner, Nick Bosa and this stacked defense. The mismatch is just as bad when the 49ers have the ball; the Giants have not generated a sack or interception this season, and Brock Purdy has not thrown any interceptions either. The Giants defense doesn't force mistakes, and Shanahan's offense doesn't make many mistakes either. George Kittle is getting healthier and this 49ers offense will score big, leading to a cover. New York RB Saquon Barkley suffered a sprained right ankle late in Sunday’s victory and is listed as questionable for this game. If Barkley can’t go in this one, the Giants will be minus their best weapon and that will make things an even steeper climb. In the end, the 49ers are clearly the better team and are poised to exploit the weaknesses of the Giants to run their record to 3-0 with a convincing triumph. The Giants were unequipped to protect Daniel Jones against the Cowboys and will have the same issue in this spot. Take the 49ers to win and cover at home. Final Score Prediction, San Francisco 49ers win 31-14. Lay the points!!!!!!!!!!!!!!!!!!!!!