Patriots loss to the Giants is the only time I have been physically ill from being a sports fan. When they missed the playoffs the next year there was the satisfaction of being the only 11 win team ever to do so (since they last expanded)
But those are unique. Haven't seen any other team lose at the very end, but doubtful it will have the same impact. When the Red Sox lost in 2008, it was a lot better than the way this year is going