Have you seen Houston's Defense, neither has anyone else.
East Carolina is a running team that doesn't put up big numbers. Plus their starting RB and tackle are out.
Unfortunately for them, their defense is dinged badly as well.
Houston is running Texas Tech's offense (hired their OC to run it) and scoring nicely while passing for 400 yards a game.
If you look at East Carolina's defense last year, the scores against teams who passed well were 45-42, 34-31, 37-35, and 56-40. They can't stop this type of offense and have not shown they can put up big points this year yet with the injuries.
Houston can definitely win this game outright.