Now by no means are we suggesting that anyone should have bet Appalachian State over Michigan or Stanford over USC. In fact, there was no money line available on Appalachian State since they are a Division I-AA school, and Stanford closed at around +4500 on the ML, not even close to the BE of +6664 for road underdogs of +27 or more
http://www.sbrforum.com/Betting+Articles/NCAAF/5642/when-bet-ncaa-football-money-line-underdogs.aspx
Oklahoma -76 Points. Sometime in the mid-80's
I don't know if this is the highest ever,this is the highest that I know of.
Railbird had both winners on the ML , he told me the next day in a PM.
I believe him too.
I remember OU and NEB used to routinely be favored by 40-50 pts back when the Big 8 was still around and teams like Kans and K State and I State were absolutely horrible.