Titans vs. Bills: Monday Night Football Doubleheader Pick for NFL Week 2

Josh Allen Buffalo Bills Los Angeles Rams
Quarterback Josh Allen #17 of the Buffalo Bills reacts with running back Devin Singletary #26 against the Los Angeles Rams. Harry How/Getty Images/AFP.

A twin bill is on tap for Week 2’s Monday Night Football but we will focus our attention on the early game which is an AFC matchup between the Titans and Bills in Orchard Park, New York.

Let’s take an early look at this one as we look to cash our NFL picks!

Tennessee Titans vs. Buffalo Bills

Monday, September 19, 2022 – 07:15 PM EDT at Highmark Stadium

Titans Ruined It Up

The Titans built a 13-point lead over the Giants last week but couldn’t stop Saquon Barkley from shredding their defensive front and amassing 164 of the 238 rushing yards they would surrender to New York’s ground attack.

“When you don’t play your gaps or you don’t tackle, it’s a very unforgiving league especially with a good back or an excellent back,” Titans coach Mike Vrabel said.

The NFL odds at all of the best sportsbooks had Tennessee as anywhere from a 5 to a 6-point home favorite. But when the dust settled, the Titans bowed 21-20, after Big Blue eschewed the extra point and decided on a two-point conversion to claim the stunning one-point victory in Nashville.

Derrick Henry was held to only 82 yards and Ryan Tannehill lived up to his reputation as being cautious and reliable, albeit unspectacular, ala Teddy Bridgewater, connecting on 20-of-33 for 266 yards with a pair of touchdown passes and no interceptions.

Bills Fly High in Opener

A clash between the defending Super Bowl champions and the team that is favored to knock them from that lofty perch this season took center stage in the league’s season opener on Thursday. But only the first half matched the hype heading into the game as the Bills throttled the Rams once the second half began, scoring 21 unanswered points to claim a 31-10 victory.

“There’s a lot to learn, but that second half, that’s who we want to be, going out there and executing that way,” said Bills quarterback Josh Allen. “We were 90% on third down. That’s a recipe for success.”

Allen was sharp in completing 26-of-31 passes for 297 yards with 3 touchdowns and a pair of interceptions. The Bills’ field marshal was also the team rushing leader with 56 yards on 10 carries and a scamper into the end zone. Not surprisingly, Stefon Diggs led all receivers with 122 yards on 8 receptions and a touchdown.

But not to be overlooked was the Bills’ defense that sacked Rams quarterback, Matthew Stafford, a total of 7 times for 49 yards, with the recently acquired Von Miller responsible for 2 of those sacks. The Buffalo secondary held the prolific passer and newly-minted Super Bowl champ to just one touchdown and forced 3 interceptions.

Titans vs. Bills: Betting Pick and Prediction

Things to Consider

The public will reflexively bet on the Bills because that’s what happens when you analyze every week in a vacuum, especially when one team is a household name on the precipice of Super Bowl greatness. As of this early writing, the best online sportsbooks are dealing Buffalo anywhere from -9 ½ to a -10-point home favorite.

But there are a few things to consider before we spontaneously follow the public and lay the big number with Buffalo.

• First, the Titans have won their last two meetings with the Bills.

• Second, Derrick Henry has scored 5 touchdowns in those two Tennessee victories.

But there are some other things to consider.

• A.J. Brown is no longer with the Titans and he was responsible for 14 receptions, 173 yards, and a touchdown in those games

• The Bills were without the menacing Von Miller on defense.

Our NFL Pick

We should also note that there is an undeniable revenge factor working in favor of the hometown Bills.

If the Titans are going to try to play smash-mouth football using Derrick Henry as the battering ram, then they better build a lead because once the Bills’ aerial attack starts clicking, a running game won’t work if Tennessee falls behind early.

Scoring Prediction: Bills 33 – Titans 17

NFL Pick: Bills -9 ½ (-110) at FanDuel