English Premier League Matchday 16 Best Bets for the Weekend

Liverpool Uruguayan striker Darwin Nunez celebrates
Liverpool’s Uruguayan striker Darwin Nunez celebrates. (Photo by Oli SCARFF / AFP)

The English Premier League returns to action on Saturday, November 12, and Sunday, November 13, for its matchday 16 installments of elite-level domestic soccer.

The Premier League odds are widely available as we provide more expert analysis, best bets, and free betting predictions.

Continue reading for our betting advice, analysis, and free soccer picks for Saturday’s fixtures involving Manchester City vs. Brentford and Liverpool vs. Southampton.


Manchester City FC vs. Brentford FC

Saturday, November 12, 2022 – 07:30 AM EST at Etihad Stadium


Citizens Are Unstoppable at Home

Manchester City returns to domestic action following a midweek Carabao Cup success over top-six rivals Chelsea. Pep Guardiola and co. will be confident in claiming all three points as the Cityzens are now riding a 16-game win streak at the Etihad Stadium.

Despite falling to 10 men against Fulham last weekend, City superstar Erling Haaland delivered the game-winning penalty in a last-gasp injury time winner. The Norwegian’s fitness levels remain unknown, but a struggling road team in Brentford shouldn’t give the EPL champions much to worry about.

Bees Can’t Sting as Visitors

English League Two side Gillingham eliminated Brentford from the Carabao Cup midweek, pushing the struggling EPL side to five consecutive games without a win. Appalling defense when playing away from home has been the culprit, and they remain winless on the road during domestic action, as 17 of their 24 goals were conceded on their travels.

Alarmingly, Brentford has conceded 11 goals from their previous 3 away games. Now, they’re faced with Guardiola’s side, who’ve scored 41 goals in 11 competitive games at the Etihad this term.

Pick and Prediction

The available EPL odds heavily favor the home side with a -700 moneyline. However, as Manchester City has scored at least three goals in eight of their home games in all competitions, expecting a complete dismantling of a weak Brentford defense can provide some betting value.

Over 2.5 goals team goals for Manchester City is the best bet in a game with the potential to end 4-0 or 5-0.

Score Prediction: Man City 4 – Brentford 0

Soccer Pick: Man City – Over 2.5 Team Goals (-154) [154$ stake returns $100 profit] at FanDuel


Liverpool FC vs. Southampton FC

Saturday, November 12, 2022 – 10:00 AM EST at Anfield


Lacking Goals

Given the contrasting form of Liverpool and Southampton, we’d usually side with a Reds 3-0 or 4-0 victory this weekend. However, Jurgen Klopp’s men haven’t provided clinical decision-making in the final third this season, aside from dismantling Bournemouth in September. On paper, the Reds have netted 18 goals at Anfield this season, but 50% of those came from the Bournemouth meeting.

While we shouldn’t be worried that Liverpool can’t take all three points this weekend, they’ve notably failed to score more than two goals in 7 of their previous 9 home fixtures.

However, sitting behind a four-game win streak for the first time this season is building momentum for the Merseyside team. And although the Saints can keep it close, as most teams have recently, it should be expected that the home side will enter the World Cup break on a positive.

EPL Debut for Nathan Jones

Newly appointed Southampton manager Nathan Jones won’t have it easy in his debut as a Premier League coach. A trip to Anfield last month wouldn’t have seemed as daunting, but now that Klopp’s side has found their domestic form, the former Luton boss will need a miracle to fix Southampton’s lack of threat in the final third.

The Saints are faced with a Liverpool squad that’s kept 5 clean sheets from their last 6 meetings at Anfield. To make matters worse, Southampton has scored just one goal in their previous five EPL road games.

Pick and Prediction

The available EPL odds at the best sportsbooks expect a home win, and so do we. A new manager isn’t going to give Southampton life at Anfield, and the Saints have struggled to score at the best of times.

The Liverpool moneyline isn’t providing much value, but plus-money can be found in the expectation that the Reds will remain sturdy in defense and collect another clean sheet.

Score Prediction: Liverpool 2 – Southampton 0

Soccer Pick: Liverpool Win to Nil (+120) [100$ stake returns $120 profit] at PointsBet